Research & Clinical Excellence

IPSO Trial – Impact of Parental Support on Pregnancy Outcomes

ACRM is currently recruiting healthy women undergoing In Vitro Fertilization (IVF) between the ages of 35 to 42 years to participate in a randomized, study. 

The purpose of the study is to determine whether PGS - testing of embryos created during IVF for chromosome abnormalities, prior to transfer to the uterus - improves pregnancy and implantation rates in patients when compared to patients whose embryos are not tested.  PGS will be conducted using 24 Chromosome Aneuploidy Screening with Parental SupportTM from Gene Security Network.

Ground breaking Robotic Surgery

Occasionally, infertility patients require reproductive surgery to enhance their chance of conceiving.  ACRM is one of the few infertility clinics in Atlanta that offers minimally invasive surgery using the technologically advanced da Vinci Surgical System.  Dr. Robin Fogle has undergone extensive training in order to use and make this state of the art robotic surgical system available to ACRM patients.

Antimullerian hormone (AMH) efficiency curves: Predicting a threshold for pregnancy in in vitro fertilization (IVF) cycles

Antimullerian hormone (AMH) is a protein secreted by small follicles of the ovary.  It is one of the best markers of ovarian reserve available.  But its ability to predict the likelihood of pregnancy in an IVF cycle is less well understood.  We are currently analyzing our clinic data to help determine if there is an AMH cutoff below which IVF is not a viable option for treatment.

A prospective, randomized clinical trial comparing the effect of metformin on pregnancy outcomes in women undergoing in vitro fertilization (IVF)

Metformin is a medication traditionally used in diabetic patients to improve insulin sensitivity.  Its applications have extended far beyond that limited patient population in recent years. Metformin use in in vitro fertilization (IVF) patients with polycystic ovary syndrome (PCOS) is now a common practice.  Some studies have demonstrated higher clinical pregnancy rates when the medication is utilized.  Others have shown no benefits in pregnancy or live birth rates but have demonstrated a decreased incidence of ovarian hyperstimulation syndrome.  However, the effects of empiric metformin use by non-PCOS patients undergoing IVF have not been studied in a randomized fashion. 

Additional Studies Currently Underway at ACRM

1. Timing of Luteal Phase Support in IVF and Pregnancy Outcomes -- a National Survey [Fogle & Toner]

 

2. Relationship between serum Progesterone levels and Pregnancy Outcomes in IVF cycles using vaginal Progesterone for Luteal Support [Toner]

 

3. Effect of Route of Progesterone administration on Pregnancy Rates in various types of Assisted Reproduction [Toner].

 

4. Impact of 24 Chromosome Aneuploidy Screening on Implantation and Pregnancy Rates in IVF [GSN; Toner].

Egg Freezing

ACRM received a substantial research grant from Gerald J. and Dorothy R. Friedman Foundation for Medical Research to aid in egg freezing clinical studies. The study conducted under this grant was completed in 2005.

Publications & Presentations

View the list of publications produced by the Atlanta Center for Reproductive Medicine.